Ubiquitin-like proteins and their roles in archaea

• Autores: Julie A. Maupin Furlow
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 21, Nº. 1, 2013, págs. 31-38
• Idioma: inglés
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• Resumen

  • This review highlights the finding that ubiquitin-like (Ubl) proteins of archaea (termed SAMPs) function not only as sulfur carriers but also as protein modifiers. UbaA (an E1 ubiquitin-activating enzyme homolog of archaea) is required for the SAMPs to be covalently attached to proteins. The SAMPs and UbaA are also needed to form sulfur-containing biomolecules (e.g., thiolated tRNA and molybdenum cofactor). These findings provide a new perspective on how Ubl proteins can serve as both sulfur carriers and protein modifiers in the absence of canonical E2 ubiquitin conjugating or E3 ubiquitin ligase enzyme homologs.