Resting Metabolic Rate in Old-Old Women with and without Frailty:: Variability and Estimation of Energy Requirements

• Autores: Carlos O. Weiss, Anne R. Cappola, Ravi Varadhan, Linda P. Fried
• Localización: Journal of the American Geriatrics Society, ISSN 0002-8614, Vol. 60, Nº. 9, 2012, págs. 1695-1700
• Idioma: inglés
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• Resumen

  • Objectives: To measure resting metabolic rate (RMR) in old-old adults living in the community and examine the association between measured RMR and frailty status and compare it with expected RMR generated by a predictive equation.

    Design: Physiological substudy conducted as a home visit within an observational cohort study.

    Setting: Baltimore City and County, Maryland.

    Participants: Seventy-seven women aged 83 to 93 enrolled in the Women's Health and Aging Study II.

    Measurements: Resting metabolic rate with indirect calorimetry, frailty status, fat-free mass, ambient and body temperature, expected RMR according to the Mifflin-St. Jeor equation.

    Results: Average RMR was 1,119 ± 205 kcal/d (range 595�1,560 kcal/d). Agreement between observed and expected RMR was biased and poor (between-subject coefficient of variation 38.0%, 95% confidence interval = 35.1�40.8). Variability of RMR was greater in frail individuals (heteroscedasticity F-test P = .02). Low and high RMR were associated with being frail (odds ratio 5.4, P = .04) and slower self-selected walking speed (P < .001) after adjustment for covariates.

    Conclusion: Equations to predict RMR that are not validated in old-old adults appear to correlate poorly with measured RMR. RMR is highly variable in old-old women, with deviations from the mean predicting clinical frailty. These exploratory findings suggest a pathway to clinical frailty through high or low RMR.