Indicadores clínicos precoces de los trastornos generalizados del desarrollo

• Autores: A. García Ron, F. Carratalá, P. Andreo-Lillo, J.L. Mestre-Ricote, Manuel Moya Benavent
• Localización: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP ), ISSN-e 1696-4608, ISSN 1695-4033, Vol. 77, Nº. 3, 2012, págs. 171-175
• Idioma: español
• Títulos paralelos:
  • Early clinical indicators of pervasive development disorders
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• Dialnet Métricas: 1 Cita
• Resumen

  • Introduction: Pervasive development disorders (PDD) conditions characterised by de?cits in many areas of behaviour, such as delay in social interactions, abnormalities in verbal and non-verbal communication, and the presence of the restrictive and repetitive interests. The relevance of early diagnosis is based on the fact that early intervention could have a bene?cial effect on the long term outcome. Due to the increase of the PDD diagnosis in the recent years, we aimed to study easily detectable clinical traits during the ?rst year of life, leading to an improvement in the diagnosis.

    Patients and interventions: A prospective and retrospective study was conducted on 37 PDD patients and 69 healthy controls. Somatometric and neurological examinations were performed and a questionnaire with several variables from the Modi?ed Checklist for Autism in Toddlers (M-CHAT) completed by the parents.

    Results: The male to female ratio (OR: 3.87; 95% CI: 1.23-12.96), delay in the ?rst disyllabic words (PDD = 20.1 ± 23 months vs Control = 10.8 ± 10.3 months; P < .01), absence of visual contact (OR: 0.05; 95% CI: 0.01-0.29), the lack of response to attention call (OR: 0.12; 95% CI: 0.02-0.67), and the increase in tantrums (OR: 6.37; 95% CI: 2.39-17.34), were signi?cantly higher in the PDD group.

    Conclusions: The differences detected between groups can not been considered as a diagnostic tool of certainty in this time period, however, we believe that they should be considered in the context of maturational delay, as alarm signs in infants and toddlers, as well as suggesting the existence of an early pervasive development phenotype