Eosinophilic activity and bronchial hyperresponsiveness within an asthmatic paediatric population

• Autores: A. Boumendjel, A. Tridon, M. Messarah, S. Ughetto, S. Meharzi, M. S. Boulakoud
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 40, Nº. 5, 2012, págs. 301-305
• Idioma: inglés
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• Resumen

  • Background Our study aims to assess the importance of serum eosinophil cationic protein (ECP) levels as a non-invasive marker of bronchial hyperresponsiveness (BHR) in children with asthma, and may predict objectively the asthmatic severity and sensitivities.

    Methods This study, which was carried out on 75 asthmatic patients from a paediatric population (average age: nine years old, sex-ratio M/F: 1.64), is based on both interrogation conducted by the clinician and biological explorations, essentially serological testing of ECP and eosinophilia determination, as well as the measurement of serological IgE amounts.

    Results The analysis of the questionnaires and the biological results allowed us to evaluate the clinico-biological relations within this population. ECP, more than eosinophilia, proves to be a relevant marker of asthma severity (p<0.05) and sensitivities within this given population (r=0.65).

    Conclusion We were able to show that the evaluation of the serological levels of ECP seems to be a good biological marker of asthma.