Abruption-Associated Prematurity

• Autores: Chistina S. Han, F. Schatz, Charles J. Lockwood
• Localización: Clinics in Perinatology, ISSN 0095-5108, Vol. 38, Nº. 3, 2011, págs. 407-421
• Idioma: inglés
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• Resumen

  • Chronic, subacute decidual hemorrhage (ie, abruptio placenta and retrochorionic hematoma formation) is an important contributor to preterm parturition. Such hemorrhage induces thrombin from decidual tissue factor, which plays a pivotal role in the development of preterm premature rupture of membranes and preterm delivery by acting through protease-activated receptors to promote the production of pro-inflammatory cytokines, and matrix-degrading metalloproteinases. Severe, acute abruption can lead to maternal and fetal mortality. Current management of abruption is individualized based on severity of disease, underlying etiology, and gestational age.