Innate IL-17 and IL-22 responses to enteric bacterial pathogens

• Autores: Stephen J. Rubino, Kaoru Geddes, Stephen E. Girardin
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 33, Nº. 3, 2012, págs. 112-118
• Idioma: inglés
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• Resumen

  • With the identification of T helper (Th)17 cells, a specific subset of CD4 T cells expressing interleukin (IL)-17 and IL-22, research on the function of these cytokines initially largely focused on traditional adaptive immune responses. However, IL-17 and IL-22 enhance basic innate barrier defenses at mucosal surfaces, such as antimicrobial peptide production and neutrophil recruitment; both events that occur rapidly and precede adaptive phase immunity. At the intestinal mucosal surface, it is now clear that innate lymphoid cells are also important sources of IL-17 and IL-22 during early phases of infection. Here, we discuss the function of innate IL-17- and IL-22-producing lymphocytes during enteric bacterial infection and their regulation by the intestinal microbiota, Toll-like receptors (TLRs) and Nod-like receptors (NLRs).