Increased expression of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma

• Autores: Jeng-Wei Lu, Jan-Gowth Chang, Kun-Tu Yeh, Rong-Ming Chen, Jeffrey J. P. Tsai, Wei-Wen Su, Rouh-Mei Hu
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 14, Nº. 4, 2012, págs. 287-293
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Background The purposes of the current study were to investigate whether overexpression of the PRL-1 is clinically relevant to hepatocellular carcinoma (HCC) and whether expression patterns of PRL-1 in HCC have diagnostic and prognostic value.

    Methods Immunohistochemistry analysis was performed for PRL-1 in 60 HCC samples. The data were correlated with clinicopathological features. The univariate and multivariate survival analyses were also performed to determine their prognostic significance.

    Results PRL-1 protein was overexpressed (83%) in HCC as compared with the adjacent normal tissue. PRL-1 expression was not influenced by chronic alcohol exposure or cirrhosis. High expression of PRL-1 was correlated with smoking (p=0.012), cirrhosis (p=0.047) and histological grade (p=0.055). The Kaplan-Meier survival curves showed that high PRL-1 expression related to a poor survival with statistical significance (I vs. III, p=0.010; II vs. III, p=0.001). Univariate analysis showed that PRL-1 expression was associated with tumour size, stage and PRL-1 score. Multivariate analysis revealed that the PRL-1 protein expression level was an independent factor for overall survival (HR, 5.367; 95% CI, 2.270�12.692; p=0.001). This is the first demonstration that the expression level of PRL-1 is correlated with tumour progression and prognosis in HCC.

    Conclusions Along with other results, the PRL-1 protein is a candidate biomarker and a potential target for novel therapies against human HCC progression.