Resumen de Translocaciones cromosómicas en los sarcomas de partes blandas: de la biología molecular a la aplicación clínica
J. Roma, A. Masiá, Ana Almazán Moga, M. Rebull, P. Velasco, Soledad Gallego Melcón, José Sánchez de Toledo Codina
Abstract Recent advances in the knowledge of the molecular biology of paediatric sarcomas, especially the characterisation of chromosomal translocations associated specifically with particular types of cancer, have established bases for the introduction of new diagnostic tools. This article reviews the main chromosomal translocations associated with paediatric tumours, and summarises their molecular characteristics regarding their oncogenic capabilities, possible usefulness as a differential diagnostic tools and possible correlation with clinical parameters.
