Metabolic Syndrome and Physical Performance in Elderly Men:: The Osteoporotic Fractures in Men Study

• Autores: Susan A. Everson Rose, Misti L. Paudel, Brent C. Taylor, Tien Dam, Peggy M. Cawthon, Erin LeBlanc, Elsa S. Strotmeyer, Jane A. Cauley, Marcia L. Stefanick, Elisabeth Barrett Connor, Kristine E. Ensrud
• Localización: Journal of the American Geriatrics Society, ISSN 0002-8614, Vol. 59, Nº. 8, 2011, págs. 1376-1384
• Idioma: inglés
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• Resumen

  • OBJECTIVES: To examine the association between metabolic syndrome (MetS) and objective measures of physical performance.

    DESIGN: Cross-sectional analysis of the cohort study, the Osteoporotic Fractures in Men Study.

    SETTING: Six clinical sites in the United States.

    PARTICIPANTS: Five thousand four hundred fifty-seven ambulatory men (mean age 73.6 ± 5.9).

    MEASUREMENTS: Physical performance assessed according to grip strength, narrow walk speed, walking speed, and time to complete five repeated chair stands. Individual scores were converted to quintiles (worst=1 to best=5; unable to complete=0) and summed for an overall score (mean 11.6 ± 4.3, range, 1�20). MetS was defined according to World Health Organization criteria that include evidence of glucose dysregulation (insulin resistance, diabetes mellitus, or hyperinsulinemia) and at least two additional characteristics: high blood pressure, low high-density lipoprotein cholesterol, high triglycerides, obesity.

    RESULTS: More than one-quarter (26.3%) of participants met criteria for MetS. In separate linear regression models, four of five MetS components were related to performance (P<.001); only high blood pressure was unrelated. Men with MetS had a 1.1-point lower performance score (mean 10.8, 95% confidence interval (CI)=10.6�11.0) than men without MetS (mean 11.9, 95% CI=11.8�12.0) (P<.001), adjusting for age, race, education, and site. With further covariate adjustment, this difference was reduced but remained significant (?=-0.78, P<.001). A graded association was observed between number of MetS components (0, 1, 2, or ?3) and performance (P for trend <.001). Findings were similar excluding men with diabetes mellitus or obese men.

    CONCLUSION: Metabolic dysregulation is related to objectively assessed poorer physical performance in relatively healthy older men.