Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys

• Paola Heman ^[2] ; Carlos Barcia González ^[2] ; Aurora Gómez ^[2] ; Carmen María Ros Tristán ^[2] ; Francisco Ros Bernal ^[2] ; José Enrique Yuste ^[2] ; Vicente de Pablos ^[2] ; Emiliano Fernandez-Villalba ^[2] ; Rebeca Toledo Cárdenas ^[1] ; María Trinidad Herrero Ezquerro ^[2]
  1. [1] Universidad Veracruzana

     Universidad Veracruzana

     México

     
  2. [2] Clinical and Experimental Neuroscience
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 27, Nº. 1, 2012, págs. 89-94
• Idioma: inglés
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• Resumen

  • In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson�s disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism.