The use of the orthotopic model to validate antivascular therapies for cancer

• Autores: Monica Loi, Daniela Di Paolo, Pamela Becherini, Alessia Zorzoli, Patrizia Perri, Roberta Carosio, Michele Cilli, Domenico Ribatti, Chiara Brignole, Gabriella Pagnan, Mirco Ponzoni, Fabio Pastorino
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 55, Nº. 4-5, 2011 (Ejemplar dedicado a: Angiogenesis in development & cancer), págs. 547-555
• Idioma: inglés
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• Resumen

  • The orthotopic model reproduces aspects of the tumour microenvironment and emulates a number of important biological features of cancer progression, angiogenesis, metastasis and resistance. Due to its parallels with human cancer, the model can be used to evaluate therapeutic responses to various therapies. This review outlines the importance of using the orthotopic implantation of tumour cells in mice models for evaluating the effectiveness of antivascular therapies.