Resumen de RP-HPLC method for simultaneous estimation of atorvastatin calcium and ramipril from plasma.

V.H. Potdar, V.S. Mule, S.A. Pishawikar, S.D. Jadhav, S.L. Thamake

• español

  Las microparticulas lipidicas solidas (MLS) cargadas con ketoprofeno se prepararon a traves del metodo de evaporacion del disolvente en emulsion simple, en el que se ha utilizado monoestearato de glicerilo y Tween 80. El tamano de la particula resulto ser de 99,80¡¾2,1 ¥ìm. Las microparticulas observadas a traves del microscopio electronico de barrido (MEB) mostraron una forma esferica. La eficacia de captura (EC %) y la capacidad de carga (CC %) del farmaco resultaron ser del 72,60¡¾1,6% y 17,98¡¾0,7%, respectivamente. Los resultados de la evaluacion de estabilidad mostraron una estabilidad relativa a largo plazo, despues de una conservacion a 4¢ªC durante 3 meses. El estudio in vivo revelo un ligero mejor porcentaje en la inhibicion del dolor, concretamente, un 74% en comparacion con un 68% producido por un farmaco corriente.

• English

  Solid lipid microparticles (SLMs) loaded with ketoprofen were prepared by single emulsion-solvent evaporation method, in which glyceryl monostearate and Tween 80 were employed. The particle size was found to be 99.80¡¾2.1¥ìm. Microparticles observed by scanning electron microscope (SEM) showed spherical shape. The entrapment efficiency (EE %) and drug loading capacity (DL %) were found to be 72.60¡¾1.6 % and 17.98¡¾0.7% respectively. Results of stability evaluation showed relatively long term stability after storage at 4¢ªC for 3 months. The in-vivo study revealed slightly better per cent inhibition of pain i.e. 74% in comparison with 68% produced by plain drug.