Regulating the acrosome reaction

• Autores: Harvey M. Florman, Melissa K. Jungnickel, Keith A. Sutton
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 52, Nº. 5-6, 2008 (Ejemplar dedicado a: Fertilization / coord. por P. M. Wassarman, Victor D. Vacquier), págs. 503-510
• Idioma: inglés
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• Resumen

  • The acrosome reaction is a secretory event that must be completed by the sperm of many animal species prior to fusion with eggs. In mammals, exocytosis in triggered by ZP3, a glycoprotein component of the egg pellucida, following gamete contact. ZP3 promotes a sustained influx of Ca2+ into sperm that is necessary for the acrosome reaction. Here, we discuss the mechanism by which ZP3 generates Ca2+ entry, as well as the upstream events leading to this influx and downstream processes that couple it with exocytosis.