Expression of zinc transporter family genes in "Dictyostelium"

• Autores: Nobuya Sunaga, Meri Monna, Nao Shimada, Mai Tsukamoto, Takefumi Kawata
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 52, Nº. 4, 2008, págs. 377-381
• Idioma: inglés
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• Resumen

  • Regulation of the zinc ion concentration is physiologically important to control the activities of a variety of cellular molecules. A BLAST search against a conserved domain of known zinc transporters identified twelve putative zinc transporter family genes in the Dictyostelium genome. Phylogenetic analysis revealed the presence of three zinc transporter subfamilies in Dictyostelium. One subfamily of proteins, consisting of the ZntA-D proteins, has weak homology to the STAT3-inducible LIV-1 protein. In addition, in situ hybridization revealed that the zntA-D genes are expressed in the pstAB cells, this expression being absent in the Dd-STATa null mutant. Thus, Dd-STATa may control stalk cell differentiation through some members of the zinc transporter family genes during Dictyostelium development.