Heat Shock Proteins Are Important Mediators of Skeletal Muscle Insulin Sensitivity

• Autores: Paige C. Geiger, Anisha A. Gupte
• Localización: Exercise and sport sciences reviews: a quarterly publication of the American College of Sports Medicine, ISSN 0091-6331, Vol. 39, Nº. 1, 2011, págs. 34-42
• Idioma: inglés
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• Resumen

  • Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.