Aging, Persistent Viral Infections, and Immunosenescence: Can Exercise "Make Space"?

• Autores: Richard J. Simpson
• Localización: Exercise and sport sciences reviews: a quarterly publication of the American College of Sports Medicine, ISSN 0091-6331, Vol. 39, Nº. 1, 2011, págs. 23-33
• Idioma: inglés
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• Resumen

  • Overcrowding the immune space with excess clones of viral-specific T cells causes the naïve T-cell repertoire to shrink, which increases infection susceptibility to novel pathogens. Physical exercise preferentially mobilizes senescent T cells from the peripheral tissues into the blood, which might facilitate their subsequent apoptosis and create "vacant space" for newly functional T cells to occupy and expand the naïve T-cell repertoire