Concepts for the cure of cancer by epigenetically inducing redysdifferentiation

• Autores: Ronald Lee Hancock
• Localización: Ludus vitalis: revista de filosofía de las ciencias de la vida = journal of philosophy of life sciences = revue de philosophie des sciences de la vie, ISSN 1133-5165, Vol. 18, Nº. 33, 2010, págs. 187-194
• Idioma: inglés
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• Resumen

  • The understanding of the biochemical mechanisms for a derivation of a cure for cancer requires guiding biological concepts. This paper is an attempt to create a generalized fundamental biological basis for such a cure. One of the major approaches stems from the idea that a neoplastic cell is in a dysdifferentiated state that involves derepressed embryonic type genes by processes of deheteochromatization. The reversal of this process by alterations in specific methylation patterns of embryonically active region of chromatin, hence epigenetic changes, in growth factor genes could be key in a curative approach to cancer treatment.