Substrate Utilization during and after Exercise in Mild Cystic Fibrosis

• Autores: Laurie Wideman, Carol F. Baker, Pamela K. Brown, Leslie A. Consitt, Walter T. Ambrosius, Michael S. Schechter
• Localización: Medicine & Science in Sports & exercise: Official Journal of the American College of Sports Medicine, ISSN 0195-9131, Vol. 41, Nº. 2, 2009, págs. 270-278
• Idioma: inglés
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• Resumen

  • Purpose: To determine substrate utilization and energy expenditure during maximal and submaximal exercise and recovery in adolescents with cystic fibrosis (CF) and healthy age-matched controls (C).

    Methods: Ten clinically stable CF patients (four girls, six boys; age = 10-22 yr) were matched by body mass index, age, gender, and Tanner stage to healthy controls. Subjects completed V[spacing dot above]O2peak testing and submaximal exercise (20 min) on a cycle ergometer at a relative intensity of 50% V[spacing dot above]O2peak and at an absolute power output (PO). Metabolic parameters were assessed during exercise and recovery (20 min).

    Results: Similar respiratory quotient (RQ) values occurred in both groups during maximal exercise and recovery, despite differences in the maximal PO [CF = 114 (60-180) W and C = 171 (105-280) W, P = 0.006], the total work completed [CF = 27 (9.0-54.3) kJ and C = 55 (25.3-126.5) kJ, P = 0.008], or the V[spacing dot above]O2peak value attained [CF = 30.6 (8.5-45.2) mL[middle dot]kg-1[middle dot]min-1 and C = 40.6 (29-64.5) mL[middle dot]kg-1[middle dot]min-1, P = 0.027]. Submaximal exercise at the same absolute PO resulted in similar RQ values during exercise and recovery despite higher heart rates and average V[spacing dot above]O2 [CF = 18.8 (9.3-28.7) mL[middle dot]kg-1[middle dot]min-1 and C = 15.2 (6.5-20.1) mL[middle dot]kg-1[middle dot]min-1, P = 0.031] values in CF adolescents, and submaximal exercise at the same relative intensity also resulted in similar RQ values despite significantly greater average PO in the C group [CF = 38.7 (12.3-80) W and C = 67.8 (25.5-140) W, P = 0.039]. Excess postexercise oxygen consumption (EPOC) was greater in CF [2.79 (1.14-5.24) L O2] than C [1.46 (0.56-2.80) L O2] after submaximal exercise at a fixed PO (P = 0.036) but not after the relative exercise bout.

    Conclusions: Habitual physical activity participation does not warrant adjustment of macronutrient intake ratios in adolescents with mild to moderate CF, but total caloric intake may need to be increased based on the level of EPOC and upon the intensity and the duration of the habitual activity.