Nhlh2: A Basic Helix-Loop-Helix Transcription Factor Controlling Physical Activity

• Autores: Deborah J. Good, Christopher A. Coyle, Dana L. Fox
• Localización: Exercise and sport sciences reviews: a quarterly publication of the American College of Sports Medicine, ISSN 0091-6331, Vol. 36, Nº. 4, 2008, págs. 187-192
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.