Vigorous Exercise and Diabetic, Hypertensive, and Hypercholesterolemia Medication Use

• Autores: Paul T. Williams, B. Franklin
• Localización: Medicine & Science in Sports & exercise: Official Journal of the American College of Sports Medicine, ISSN 0195-9131, Vol. 39, Nº. 11, 2007, págs. 1933-1941
• Idioma: inglés
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• Resumen

  • Purpose: The prevalences of diabetes, hypertension, and high cholesterol all decrease with increased levels of physical activity and cardiorespiratory fitness. Whether these reductions extend beyond contemporary guideline activity levels and whether fitness affects medication use independent of activity, remains unclear.

    Methods: Cross-sectional analyses of 62,291 male and 45,041 female runners, of whom 496 used antidiabetic, 3738 used antihypertension, and 2360 used low-density lipoprotein cholesterol (LDL-C)-lowering medications. Cardiorespiratory fitness was reported as speed (m[middle dot]s-1) during a 10-km foot race.

    Results: Medication use was significantly inversely associated with activity and fitness (P < 0.001, except LDL-C-lowering versus women's fitness). Compared with <= 16 km[middle dot]wk-1 (guideline levels), the odds in men and women who ran > 64 km[middle dot]wk-1 were, respectively, 69% and 55% lower for antidiabetic, 48% and 52% lower for antihypertension, and 64% and 51% lower for LDL-C-lowering medication use. Compared with the least-fit men (< 3.25 m[middle dot]s-1) and women (< 2.8 m[middle dot]s-1), the odds for those who were most fit (men > 4.75 m[middle dot]s-1; women > 4.0 m[middle dot]s-1) were 58% and 65% lower for antidiabetic, and 76% and 55% lower for antihypertensive medication use. Odds for LDL-C-lowering medication use were 87% lower in the fittest versus the least-fit men. Adjustment for activity only moderately diminished the inverse relationships of fitness with medication use.

    Conclusion: Among individuals who exceed current guideline levels, antidiabetic, antihypertension, and LDL-C-lowering medications are inversely related to vigorous physical activity and cardiorespiratory fitness. Lower odds of medication use with higher fitness occur independently of physical activity.