The prevalence of aspirin-induced asthma in Saudian asthmatic patients.

• Autores: E.Y. Sabry
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 38, Nº. 4, 2010, págs. 181-186
• Idioma: inglés
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• Resumen

  • Background Aspirin-induced asthma (AIA), is a distinct clinical syndrome affecting some asthmatic patients. Although the name of the condition relates to aspirin, it is well established that affected patients are cross-sensitive to all non-steroidal anti-inflammatory drugs (NSAIDs).

    Objectives Assessing the prevalence of AIA among Saudian asthmatic patients.

    Methods This is a retrospective study of the medical records of asthmatic patients.

    Results The prevalence of AIA in the patients studied was found to be 12.6%. Statistical analyses indicated that AIA was associated with more severe asthma [odds ratio (OR) (95% Confidence interval (CI)) in Group I cases 2.86 (1.24 to 6.59) respectively (p<0.05)]. The results showed that some allergic conditions were significantly more common in Group I for allergic rhinitis (OR=2.19, 95% CI 0.89�5.37, p<0.05), pollinosis (OR=1.59, 95% CI 0.85�2.98, p<0.05) for antibiotic allergy (OR=1.25, 95% CI 0.65�2.41, p<0.05) and for atopic dermatitis (OR=1.34, 95% CI 0.70�2.55, p<0.05). Family history of allergy had a more significant role in Group I cases (OR=1.27, 95% CI 0.68�2.37, p<0.05). No gender difference on asthma severity was detected in either group (Chi2=2.19, p>0.05).

    Conclusion The prevalence of respiratory symptoms triggered by aspirin/NSAID use was 12.6% in the asthmatics studied. AIA appears to be a significant problem and further investigations of the mechanisms of these responses and the possible link between this syndrome and other allergic co-morbidities are required.