The kinetics and distribution of different macrophage populations in the developing rat skin

• Autores: Vetnizah Juniantito, Takeshi Izawa, Emi Yamamoto, Mitsuru Kuwamura, Jyoji Yamate
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 25, Nº. 8, 2010, págs. 985-994
• Idioma: inglés
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• Resumen

  • Macrophages play important roles in host defense and homostasis. In contrat to adulthood, far less is known about macriphage populations in fetuses and neonates. Macrophages were evaluated in the developing rat skin at diffrent anatomical sited (head, anterior dorsal, posterior dorsal, and abdomen) of F344 rats obtained on gestational days 18 and 20, on neonatal days 1-21, and to adult weeks 5-15. The numbers of macrophages in the epidermis, dermis or perifollicular areas that were positive for ED1 (exudative macrophages), and OX6 (antigen-presenting cells) were evaluated. There were no diffrences in macrophage numbers among the anatomical sites. In the epidermis, only OX6 cells were seen, with gardually increased numbers in neonates and adults. In the dermis, many ED1 cells were already seen in fetuses, and the number peaked on neonatal day 4, and remained at that level until adulthood. By contrast, ED2 and OX6 cells began to be seen after birth and their numbers continued to increase until adulthood; ED2 cells were distributed diffusely in the dermis, whereas ED1 and OX6 cells were present exclusively in the upper dermis.