Resumen de Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials
Airo Tsubura, Kazuyuki Yoshizawa, M. Kuwata, N. Uehara
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptors cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retianl degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanism, and therapeutic trials of MNU-induced retinal degeneration.
