Inflamación neurogénica: mecanismos y oportunidades dermocosmecéuticas
- Autores: Antonio Ferrer Montiel
- Localización: Anales de la Real Academia Nacional de Farmacia, ISSN-e 1697-4298, ISSN 0034-0618, Nº. 4 2, 2009, págs. 255-272
- Idioma: español
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Resumen
Cutaneous neurogenic inflammation is emerging as the cause of diverse skin conditions, as well as dermatological diseases. The intimate interplay between the dermal immune system and the peripheral nervous system is central for the biology and physiology of the skin. A dysfunction in this interaction gives rise to an inflammatory state that is strengthened by the complementarity of both cellular systems. Cumulative evidence is signalling to TRPV1 as a key player in the onset and maintenance of neurogenic inflammation. This thermoreceptor is activated by physical and chemical stimuli, and its ion channel activity is notably enhanced by pro-inflammatory mediators such as neurotrophins, interleukin, kinins and ATP. An increment of TRPV1 activity results in an augment of neuronal excitability which, in turn, induces the release of substance P (SP) and a-calcitonin gen-related peptide (a-CGRP) that paracrinally act and stimulate peripheral immune cells provoking the release of additional pro-algesic agents. Therefore, TRPV1 receptor is being considered as a dermatological and cosmeceutical target and compounds that reduce its activity will be useful dermocosmetics for the treatment of several cutaneous conditions
