Neonatal sepsis and later development of atopy

• Autores: Diego Peroni
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 37, Nº. 6, 2009, págs. 281-284
• Idioma: inglés
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• Resumen

  • Asthma and allergy inflammatory responses are associated with immune shift toward Th2 phenotype with consequent over-production of Th2-associated cytokines and inflammatory mediators.

    According to the hygiene hypothesis, an early infection during childhood could downreg ...

    Allergol Immunopathol (Madr). 2009;37:281-4.

    Neonatal sepsis and later development of atopy jueves, 10 dic 2009 Background The role of infections on the development of atopy is still widely debated. We aimed to evaluate the effects of neonatal severe sepsis and consequent antibiotic treatment on the development of atopy and allergic diseases.

    Material and methods A retrospective enrolment at school age of children with a clear history of neonatal sepsis (NS) was performed from registers of neonatal intensive care units. A normal control was assigned to each patient with sepsis. Thirty six cases with sepsis (18 males, 18 females) and 36 controls (21 males, 15 females) were selected (8.5±3.6 yrs). Physical examination and lung function evaluation were performed. Atopic status was verified by blood eosinophil count, total IgE serum level and skin prick tests (SPT).

    Results SPT positivity for at least one allergen was present in 30% of subjects in both groups. No difference for all investigated parameters between groups and no influence by other factors such as familiarity or gender was observed. No correlation was associated to NS history.

    Conclusions Neonatal sepsis, even if clinically severe and dramatic, could represent an event too limited and really precocious in life to influence the development of immune response. Furthermore, other factors, besides infections, may influence the atopic future of newborns.