Kinesin motors and disease: Review

• Autores: Eckhard Mandelkow, Eva-Maria Mandelkow
• Localización: Trends in cell biology, ISSN 0962-8924, Vol. 12, Nº 12, 2002, págs. 585-591
• Idioma: inglés
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• Resumen

  • Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a diverse family of kinesins, members of which differ in composition and functions. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.