Intraflagellar transport and cilia-dependent diseases

• Gregory J. Pazour ^[1] ; Joel L. Rosenbaum ^[2]
  1. [1] University of Massachusetts Medical School

     University of Massachusetts Medical School

     City of Worcester, Estados Unidos

     
  2. [2] Yale University

     Yale University

     Town of New Haven, Estados Unidos

     
• Localización: Trends in cell biology, ISSN 0962-8924, Vol. 12, Nº 12, 2002, págs. 551-555
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Intraflagellar transport involves the movement of large protein particles along ciliary microtubules and is required for the assembly and maintenance of eukaryotic cilia and flagella. Intraflagellar-transport defects in the mouse cause a range of diseases including polycystic kidney disease, retinal degeneration and the laterality abnormality situs inversus, highlighting the important role that motile, sensory and primary cilia play in vertebrates.