Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases

• Christian Haass ^[1] ; Harald Steiner ^[1]
  1. [1] Ludwig Maximilian University of Munich

     Ludwig Maximilian University of Munich

     Kreisfreie Stadt München, Alemania

     
• Localización: Trends in cell biology, ISSN 0962-8924, Vol. 12, Nº 12, 2002, págs. 556-562
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • γ-Secretase is a pivotal enzymatic activity in Alzheimer disease that was hidden within a huge number of unrelated proteases. Only recently it has become clear that a protease complex containing presenilin, nicastrin, PEN-2 and probably APH-1 provides the long sought γ-secretase activity. Presenilin itself appears to be a novel polytopic aspartyl protease of the GxGD type, whereas the other components might be required for substrate recognition, complex assembly, stability and targeting of the complex to its sites of action.