Macromolecular mobility inside the cell nucleus

• Maria Carmo-Fonseca ^[1] ; Melpomeni Platani ^[2] ; Jason R. Swedlow ^[2]
  1. [1] Universidade de Lisboa

     Universidade de Lisboa

     Socorro, Portugal

     
  2. [2] University of Dundee

     University of Dundee

     Reino Unido

     
• Localización: Trends in cell biology, ISSN 0962-8924, Vol. 12, Nº 11, 2002, págs. 491-495
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The highly organized interior of the living cell imposes major constraints on the dynamic properties of macromolecules and macromolecular complexes in both the cytoplasm and the nucleus. Although there are many examples of cytoplasmic molecular assemblies that can be propelled by molecular motors along microtubules and actin filaments, a view that had emerged during the past few years was that intranuclear mobility results largely from incessant Brownian motion. However, more recent studies now suggest that the movement of an increasing number of macromolecular entities inside the nucleus is controlled by a combination of passive diffusion and ATP-dependent processes.