Location, location, location: translational control in development and neurobiology

• Raúl Mendez ^[1] ; David Wells ^[2]
  1. [1] Centro de Regulación Genómica

     Centro de Regulación Genómica

     Barcelona, España

     
  2. [2] Yale University

     Yale University

     Town of New Haven, Estados Unidos

     
• Localización: Trends in cell biology, ISSN 0962-8924, Vol. 12, Nº 9, 2002, págs. 407-409
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Control of gene expression by regulating mRNA translation is essential for proper growth and development in species ranging from yeast to mammals. Recently, translational regulation has also been implicated in neuronal function, where long-lasting changes in synaptic strength and the formation of memory require new protein synthesis. Crucial to both developmental and neurobiological function, translational control allows for the asymmetric distribution of gene products and a rapid and local response to stimulation – as discussed at a recent Serono Foundation EMBO Workshop held in Mallorca, Spain.