Chemical genetics: tailoring tools for cell biology

• Thomas U. Mayer ^[1]
  1. [1] Max Planck Institute of Biochemistry

     Max Planck Institute of Biochemistry

     Kreisfreie Stadt München, Alemania

     
• Localización: Trends in cell biology, ISSN 0962-8924, Vol. 13, Nº 5, 2003, págs. 270-277
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Chemical genetics is a research approach that uses small molecules as probes to study protein functions in cells or whole organisms. Here, I review the parallels between classical genetic and chemical-genetic approaches and discuss the merits of small molecules to dissect dynamic cellular processes. I then consider the pros and cons of different screening approaches and specify strategies aimed at identifying and validating cellular target proteins. Finally, I highlight the impact of chemical genetics on our current understanding of cell biology and its potential for the future.