Protein transduction technology offers novel therapeutic approach for brain ischemia.

• Autores: Catherine Denicourt, Steven F. Dowdy
• Localización: Trends in pharmacological sciences, ISSN 0165-6147, Vol. 24, Nº 5, 2003, pág. 216
• Idioma: inglés
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• Resumen

  • Transient or permanent reduction in cerebral blood flow following ischemia can lead to severe and irreversible tissue damage to the brain. Emerging biochemical evidence suggests a role for apoptosis in neuronal death following cerebral ischemia. Despite the abundance of studies on the subject, therapeutic interventions for ischemia-related cell injury have so far proved disappointing in clinical trials. Recently, four new, exciting studies reported the use of protein transduction technology to deliver anti-apoptotic molecules to protect neuronal cells following ischemic stroke in vivo. These studies offer new avenues for the treatment and prevention of cell death following brain injuries.