p53 and Apoptosis: It's Not Just in the Nucleus Anymore

• Autores: James J. Manfredi
• Localización: Molecular cell, ISSN 1097-2765, Vol. 11, Nº 3, 2003, pág. 552
• Idioma: inglés
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• Resumen

  • The tumor suppressor p53 triggers apoptosis in response to a variety of stress stimuli. Its role as a transcription factor modulating gene expression has been clearly implicated in this process. Two recent publications now argue for an additional direct role of p53 at the mitochondria in inducing apoptosis.