Histone Deposition at the Replication Fork: A Matter of Urgency

• Autores: Alain Verreault
• Localización: Molecular cell, ISSN 1097-2765, Vol. 12, Nº 2, 2003, pág. 283
• Idioma: inglés
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• Resumen

  • In this issue of Molecular Cell, Ye et al. provide a biological rationale for rapid histone deposition behind the replication fork. They show that defects in nucleosome assembly lead to DNA double-strand breaks and S phase arrest. Their results have important implications for the maintenance of genome integrity in proliferating cells.