Effect of Running Training on DMH-Induced Aberrant Crypt Foci in Rat Colon

• Autores: Noriyuki Fuku, Masako Ochiai, Shin Terada
• Localización: Medicine & Science in Sports & exercise: Official Journal of the American College of Sports Medicine, ISSN 0195-9131, Vol. 39, Nº. 1, 2007, págs. 70-74
• Idioma: inglés
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• Resumen

  • Purpose: We examined the effects of treadmill-running training on the induction of aberrant crypt foci (ACF), which is the first step of colon cancer induction, in the colonic mucosa of rats injected with 1,2-dimethylhydrazine (DMH).

    Methods: Four-week-old F344 rats (N = 38) were randomly assigned to training (19 rats) and control (19 rats) groups. After a week, all rats were given DMH (20 mg·kg-1 body weight) once a week for 2 wk. Running training was started at age 7 wk (speed: 10 m·min-1, 0% grade, 120 min·d-1, 5 d·wk-1). After 4 wk of training, the rats were sacrificed and the colon was removed, opened, and counted for ACF with 0.2% methylene blue staining.

    Results: Running training resulted in lower body- (P < 0.01) and adipose fat weight (P < 0.05). The numbers of ACF and total AC were significantly lower in the running training group than in the control group (P < 0.05). The occurrences of one, three, and five aberrant crypts per focus were also significantly lower in the running training group than in the control group (P < 0.05). The ratios of total AC/ACF did not significantly differ between the running training and control groups.

    Conclusions: The results of the present investigation suggest that low-intensity running training inhibits the DMH-induced initiation of colon ACF development.