Efecto de diosgenina sobre la proteína C reactiva y homocisteína en pacientes menopáusicas

• Autores: Eduardo Reyna Villasmil, Jorly Mejia Montilla, Nadia Reyna Villasmil, Diana Torres, E. Peña
• Localización: Clínica e investigación en ginecología y obstetricia, ISSN 0210-573X, Vol. 35, Nº. 4, 2008, págs. 120-125
• Idioma: español
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• Resumen

  • The aim of this study was to investigate homocysteine and C-reactive protein concentrations in postmenopausal women treated with diosgenin as an alternative to hormone replacement therapy. An explanatory, prospective and longitudinal study was performed with a quasi-experimental design and non-probabilistic sampling of 49 patients who attended the menopause clinic of the Dr. Urquinaona General Hospital. Homocysteine and C-reactive protein concentrations were determined before and after 6 months of treatment with diosgenin.

    The mean age of the postmenopausal women was 51.6 +- 2.9 years. Age at menopause onset was 44.6 +- 2.1 years and the time from m e n o p a use was 45.7 +- 18.4 months. C-reactive protein concentrations were increased by more than 56% at 6 months of treatment compared with initial concentrations (P<.05). Plasma homocysteine concentrations slightly decreased (by more than 596, approximately) compared with initial concentrations (P=NS). We conclude that diosgenin significantly increases C -reactive concentrations, without modifying plasma homocysteine concentrations after 6 months of treatment.