Toll-Like Receptor 4: Link to the Anti-Inflammatory Effects of Exercise?

• Autores: Michael G. Flynn, Brian McFarlin
• Localización: Exercise and sport sciences reviews: a quarterly publication of the American College of Sports Medicine, ISSN 0091-6331, Vol. 34, Nº. 4, 2006, págs. 176-181
• Idioma: inglés
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• Resumen

  • Evidence is emerging that exercise training has anti-inflammatory effects. Our early finding that blood cultures from trained subject had a reduced responsiveness to lipopolysaccharide led to a series of studies in which we measured toll-like receptor 4-the primary signaling receptor for lipopolysaccharide. The toll-like receptor 4 expression was consistently lower in physically active subjects compared with inactive subjects and reduced after training in previously inactive subjects.