Resumen de PGC-1[alpha] Gene and Physical Activity in Type 2 Diabetes Mellitus.

Paul W. Franks, Ruth J.F. Loos

• Exercise stimulates PGC-1[alpha] gene expression and increases V[spacing dot above]O2max, the latter of which relates inversely with type 2 diabetes risk. Consistently, low levels of PGC-1[alpha] mRNA and nucleotide sequence variation at PGC-1[alpha] associate with lower level of V[spacing dot above]O2max and increased diabetes risk. Thus, PGC-1[alpha] sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism.