Resumen de Interacción "in vivo" del vanadio con cefotaxima

Pilar Madrigal, Antonio Luis Doadrio Villarejo, P. González, J. Casas

• The presence of V(IV) in penicillin and cephalosporin solutions, has been shown previously, in vitro, to promote the degradation of the penicillins and cephalosporins studied to their corresponding penicilloic and cephalosporanic acids. HPLC studies provided an additional evidence for the reaction mechanism. The mechanisms of V(IV) catalysis involve a ternary complex. This work was undertaken to study the consequences of this degradation, in vivo, upper the pharmacokinetic and pharmacodynamic of Cefotaxime, being these consequences a lower concentracion of free cefotaxime in blood, liver, spleen, kidney, lung and heart when there was intoxication with vanadium. The differences more significant between rats with vanadium and without it were observed in liver, lung and kidney.