Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes

• Autores: F. Mori, F.R. Piro, C. Della Rocca, G. Mesiti, S. Giampaoli, G. Silvestre, D. Lazzaro
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 22, Nº. 1, 2007, págs. 61-77
• Idioma: inglés
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• Resumen

  • In the evolution of colon rectal cancer (CRC) the imbalance between cell proliferation and apoptosis is considered one of the prominent causes of tumor induction and/or progression. In order to establish the role of anti apoptotic proteins in colon cancer development, we studied with immunohistochemical techniques the expression of Survivin in a mouse model of colon carcinogenesis induced by 1,2-dimethyl-hydrazine treatment.

    In this mouse model Survivin was over-expressed during tumor development, showing a distribution mimicking that described in the correspondent human malignancies. We also correlated Survivin distribution with COX-2 and ß-Catenin expression patterns.

    The co-localization of COX-2/ß-Catenin/Survivin in the same epithelial cells in tumor samples lends credence to possible in vivo regulatory effects of COX-2 and ß-Catenin on the intracellular Survivin levels in mouse and human colon cancer