Resumen de Carcinoma neuroendocrino de células grandes de pulmón: análisis de una serie de once casos en un hospital universitario
Ramón García Gómez, E. Alvarez Fernández, Federico González Aragoneses, María Cebollero Presmanes, N. Moreno, J. A. Arranz Arija, G. Abad, I. Siso, L. Iglesias, Vanesa Pachón Olmos, V. Díaz, Parham Khosravi Shahi, Gumersindo Pérez Manga
Purpose: Lung carcinomas with neuroendocrine differentiation are a heterogeneous group of tumors related to typical and atypical carcinoids, neuroendocrine large-cell carcinomas (NLCC) and small-cell lung cancer (SCLC). NLCC comprises less than 5% of non small-cell lung cancer (NSCLC). In this report, we describe a series of NLCC treated in a single institution in the last ten years. Material and methods: Eleven patients diagnosed as having NLCC (5 of them with mixed histology). Results: At diagnosis, the mean age of the patients was 66 years (5 males and 6 females); 4 had localized disease, 5 locally advanced disease, and 2 metastatic disease. Seven patients underwent initial radical surgery (2 of them followed by adjuvant chemotherapy), 1 patient received chemotherapy and radiotherapy, and 3 patients only chemotherapy. Median overall survival for the whole series was 24 months, and the overall 2-year and 5-year survival were 45% and 27% respectively. Conclusion: Our data corroborate the general recommendation of treating NLCC in a similar way as the rest of the non small-cell lung cancer (NSCLC) are treated. Radical surgery is the main treatment for localized tumors. There are no data indicating a worse response of these tumors to radiation therapy or chemotherapy.
