Sulfonamidas: el grupo mágico
- Autores: Miguel Fernández Braña, M. Cacho, C. Guisado
- Localización: Anales de la Real Academia Nacional de Farmacia, ISSN-e 1697-4298, ISSN 0034-0618, Nº. 4 2, 2006, págs. 317-341
- Idioma: español
- Títulos paralelos:
- Sulfonamide: the magic group
- Enlaces
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Resumen
The significant role of sulfonamide in the development of new drugs is shown in this article, through an overview of its history. Sulfonamide is an organic sulfur compound containing the radical �SO2NH2. Then, any sulfonamide can be considered as derived from a sulfonic acid by replacing a hydroxyl group with an amine group. The treatment of infectious diseases with sulfamides has been the result of a combination of intelligent research and «serendipity»; this is the only way to explain the development of this drugs, starting from the aniline extraction by Runge and its evolution to give the azoic dyes manufacturing. Nowadays, this magic group is present in many drugs as antibiotics, antimalaric drugs, antimicrobial agents, diuretics, hypoglycemics, anti-inflammatory drugs, antihypertensive drugs, etc. showing the broad therapeutic field of sulfonamides as therapeutic function.
