La diversidad funcional de proteína fosfatasa-1 y el papel de nuevas subunidades reguladoras

• Autores: José Miguel Ortiz Melón
• Localización: Anales de la Real Academia Nacional de Farmacia, ISSN-e 1697-4298, ISSN 0034-0618, Nº. 4 2, 2006, págs. 283-299
• Idioma: español
• Títulos paralelos:
  • The functional diversity of protein phosphatase-1 and the role of new regulatory subunits
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• Resumen

  • Reversible protein phosphorylation is a mechanism that regulates many cellular processes and in particular signal transduction. Protein phosphatase-1 (PP1) is the major group of serin/threonin protein phosphatases. PP1 regulates glycogen metabolism, intracellular transport, muscle contraction, protein synthesis and cell division. The functional diversity of PP1 is due to a small number of catalytic subunits which bind to a large number of regulatory subunits. We describe here the identification of SIPP1, a new interactor, which is an splicing factor of premRNA ands binds also PQBP-1 protein. Since mutations in PQBP-1 have been reported in cases of X-linked mental retardation and PQBP-1 binds ataxin-1 and other poliglutamine disease proteins SIPP1 could be an element in the pathogenesis of neurodegenerative disease.