Src transforms in a Cool way

• Autores: Jeffrey R. Peterson, Jonathan Chernoff
• Localización: Nature: Cell biology, ISSN 1465-7392, Nº. 9, 2006, págs. 905-907
• Idioma: inglés
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• Resumen

  • Cool-1 was previously identified as an effector of activated Cdc42 and as a regulator of epidermal growth factor receptor (EGFR) trafficking. Cool-1 has now been shown to be a phosphorylation-dependent activator of Cdc42 that contributes to transformation by Src, thus proving to be an unusually versatile signalling protein.