CFTR: helping to acidify macrophage lysosomes

• Joel Swanson ^[1]
  1. [1] University of Michigan Medical School

     University of Michigan Medical School

     City of Ann Arbor, Estados Unidos

     
• Localización: Nature: Cell biology, ISSN 1465-7392, Nº. 9, 2006, págs. 908-909
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • A new study shows that alveolar macrophages use the cystic fibrosis transmembrane-conductance regulator (CFTR) to maintain lysosomes at low pH and to restrict the growth of ingested bacteria. This may help to explain the persistent infections and chronic inflammation of the lungs that characterize cystic fibrosis.