A Hopscotch-chromatin connection

• Aurel Betz ^[1] ; James E. Darnell ^[1]
  1. [1] Rockefeller University

     Rockefeller University

     Estados Unidos

     
• Localización: Nature genetics, ISSN 1061-4036, Vol. 38, Nº. 9, 2006, págs. 977-979
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Dysregulation of the JAK-STAT pathway is implicated in human cancer and leads to a hematopoietic tumor phenotype in flies. Now, an enhancer-suppressor screen of the fly tumor model connects the JAK kinase Hopscotch pathway with chromatin-modifying proteins and heterochromatic gene silencing.