Chronic Alcohol Intake, Resistance Training, and Muscle Androgen Receptor Content

• Autores: William J. Kraemer, Lymperis P. Koziris, Scott E. Gordon, Russell T. Turner, Jakob L. Vingren
• Localización: Medicine & Science in Sports & exercise: Official Journal of the American College of Sports Medicine, ISSN 0195-9131, Vol. 37, Nº. 11, 2005, págs. 1842-1848
• Idioma: inglés
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• Resumen

  • Introduction: Chronic alcohol intake and resistance training (RT) have opposite effects on muscle physiology.

    Purpose: This study examined the effect of chronic alcohol intake on androgen receptor (AR) content in skeletal muscle to determine whether this effect was influenced by RT.

    Methods: A total of 48 male Sprague Dawley(R) rats (mass = 456 +/- 1 g; mean +/- SE) were divided into five groups: baseline (N = 8), sedentary + alcohol (Sed-Al) (N = 8), sedentary + normal diet (Sed-Nml) (N = 8), exercise + alcohol (Ex-Al) (N = 12), and exercise + normal diet (Ex-Nml) (N = 12). Exercise groups completed a 6 1/3-wk "squat" RT protocol; alcohol groups received an ethanol-rich (35% caloric content of alcohol) diet throughout the 6 1/3-wk period. Baseline animals were killed at the onset of the 6 1/3-wk training period.

    Results: Western blot analysis showed no effect of alcohol or RT on the AR of the extensor digitorum longus. Alcohol significantly reduced AR content of the rectus femoris (P < 0.05) and prevented RT-induced increases in AR content of the soleus.

    Conclusion: Chronic alcohol intake appeared to reduce the AR content of the type IIB fiber-predominant rectus femoris, and this reduction was not affected by RT. In the type I-predominant soleus, chronic alcohol intake alone had no effect but seemed to prevent RT-induced increases in AR content.