Crystal-state studies on p-toluenesulfonates of N-oxyimides¿a possible structural basis of serine proteases inhibition

• Autores: P. Stefanowicz
• Localización: New journal of chemistry, ISSN 1144-0546, Vol. 30, Nº 2, 2006, págs. 258-265
• Idioma: inglés
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• Resumen

  • A series of p-toluenesulfonates of N-oxyimides has been synthesized and their X-ray structures show a flattened pyramidal geometry of the hydroxyimide ring nitrogen. This structural feature is considered to be responsible for a specific chemical reactivity towards nucleophiles and inhibitory properties against proteases of these compounds.