Medium-term biological variation of sodium, potassium and chloride in whole blood in cohorts of healthy individuals and hemodialysis patients

• Berta Sufrate Vergara ; Isabel Moreno Parro ; Pilar Fernández Calle ; Aasne K Aarsand ^[1] ; Laboratory Medicine Department, IRCCS Ospedale San Raffaele, Milano, Italy ; Roberto Mora Corcovado ; Daniel Prieto Arribas ^[2] ; Blanca Beumer Prieto ^[2] ; José Manuel Hidalgo Fernández ; Sara Julia Molina ^[2] ; Nuria Alert Flo ; Ana Belén Monreal Tomás ; Ana Cristina Mendoza ^[3]
  1. [1] Norwegian Organization for Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital, Bergen, Norway
  2. [2] Laboratory Medicine Department, La Paz University Hospital, Madrid, Spain
  3. [3] Nephrology Department, La Paz University Hospital, Madrid, Spain

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• Localización: Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, ISSN-e 2628-491X, Nº. 7, 3, 2026, págs. 193-201
• Idioma: inglés
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  • Objectives: Biological variation (BV) refers to the fluctua tion of the concentration of a measurand around its ho meostatic set-point. While BV has been extensively studied in healthy populations, robust data for patients with chronic diseases, particularly using whole blood measurements, remain scarce. The aim of this study was to obtain BV esti mates for electrolytes in whole blood for a cohort of healthy individuals and one of hemodialysis patients (HD) and compare them with each other.