Bone marrow changes in a case of Wilson’s disease- A Case report

• Drishti Sachan ^[1] ; Kamal Shroff Nashwa ^[1] ; Komal Yadav ^[1] ; Rajeev Sen ^[1]
  1. [1] SGT Medical college and research institute, Gurugram, India
• Localización: Revista Hematología, ISSN 0329-0379, ISSN-e 2250-8309, Vol. 30, Nº. 1, 2026 (Ejemplar dedicado a: JANUARY - APRIL), págs. 83-86
• Idioma: inglés
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• Resumen

  • Background: Wilson’s disease is a rare autosomal recessive disorder of copper metabolism caused by mutation of ATP7B gene on chromosome 13 result-ing in excess accumulation of free copper in the liv-er, brain and eyes.Case presentation: We describe the case of a twelve year old boy with Wilson’s disease who developed bicytopenia. Bone marrow aspirate and biopsy was subsequently performed and the findings were ob-served. Informed consent was taken from the pa-tient before the procedure.Conclusion: Bone marrow aspirate and biopsy revealed drug induced suppression of bone mar-row. Myeloid, erythroid and megakaryocyte series showed perinuclear vacuolization along with ab-normal pigment deposition in myeloid precursors. Close monitoring of hematological parameters is re-quired while the patient is on treatment.